Study on the inhibitory effect of ulinastatin on caspase-1-dependent pyroptosis in acinar cells of acute pancreatitis

Objectives Pyroptosis, a special kind of cell death, is generally believed to aggravate the inflammatory response. It has been found that acinar pyroptosis exits in course pancreatitis. Ulinastatin function inhibiting release mediators, thereby reducing reaction, which suggests ulinastatin potential inhibitory effect on pyroptosis. The aim this study investigate caspase-1-dependent acute Methods Acute pancreatitis model was established by intraperitoneal injection L-arginine. Rats group were injected with intravenously after successful modeling. pancreatic tissues rats subjected pathological examination and detection cleaved-caspase-1, GSDMD-N, IL-1β, IL-18. Serum samples also collected for measurement IL-18, amylase, lipase. Results Slight damage pancreas observed group. Compared blank control ( p < .05), protein levels IL-18 significantly increased but decreased .05). positive reaction caspase-1 higher than After administration ulinastatin, lower As serum IL-1β they those Administration And amylase lipase elevated group, while inhibited Conclusions results showed onset accompanied obvious could inhibit